Inicio > cardiologia, diabetes, enfermedades cronicas, evidence based medicine, medicina basada en evidencia, prevencion, Uncategorized > Statins, antihypertensive treatment, and blood pressure control in clinic and over 24 hours: evidence from PHYLLIS randomised double blind trial BMJ

Statins, antihypertensive treatment, and blood pressure control in clinic and over 24 hours: evidence from PHYLLIS randomised double blind trial BMJ

ABSTRACT 

Objective reduce blood pressure as well as cholesterol concentrations through clinic and 24 hour ambulatory blood pressure monitoring. To investigate the possibility that statins Design Randomised placebo controlled double blind trial. Setting 13 hospitals in Italy Participants hypercholesterolaemia, aged 45 to 70 years. 508 patients with mild hypertension and Intervention antihypertensive treatment (hydrochlorothiazide 25 mg once daily or fosinopril 20 mg once  daily) with or without the addition of a statin (pravastatin 40 mg once daily). Participants were randomised to Main outcome measures pressure measured every year throughout an average 2. 6 year treatment period. Clinic and ambulatory blood Results treatment without pravastatin (n total cholesterol) and the group receiving antihypertensive treatment with pravastatin (n sustained reduction in total cholesterol and low density lipoprotein cholesterol) had a clear cut sustained reduction in clinic measured systolic and diastolic blood pressure as well as in 24 hour, and day and night, systolic and diastolic blood pressure. Pravastatin performed slightly worse than placebo, and between group differences did not exceed 1.9 (95% confidence interval throughout the treatment period. This was also the case when participants who remained on monotherapy with hydrochlorothiazide or fosinopril throughout the study were considered separately. Both the group receiving antihypertensive=254) (with little change in=253) (with marked and−0.6 to 4.3, P=0.13) mm Hg

 

 FULL TEXT  http://www.bmj.com/cgi/reprint/340/mar25_3/c1197

  1. Aún no hay comentarios.
  1. No trackbacks yet.

Responder

Introduce tus datos o haz clic en un icono para iniciar sesión:

Logo de WordPress.com

Estás comentando usando tu cuenta de WordPress.com. Cerrar sesión / Cambiar )

Imagen de Twitter

Estás comentando usando tu cuenta de Twitter. Cerrar sesión / Cambiar )

Foto de Facebook

Estás comentando usando tu cuenta de Facebook. Cerrar sesión / Cambiar )

Google+ photo

Estás comentando usando tu cuenta de Google+. Cerrar sesión / Cambiar )

Conectando a %s

A %d blogueros les gusta esto: